IP International Journal of Periodontology and Implantology

Autologous Platelet Rich Fibrin as a potential antiperiopathogenic agent: An in-vitro study

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Author Details: Chaitanya Pradeep Joshi, Agraja Ganpat Patil, Prerna Ashok Karde, Smita Uday Khedkar, Swapna Arunkum

Volume : 1

Issue : 2

Online ISSN : 2457-0087

Print ISSN : 2581-9836

Article First Page : 50

Article End Page : 54


Background: Lately, hard and soft tissue regeneration property of autologous platelet concentrates is gaining a lot of popularity in dental and allied fields. Along with intrinsic regenerative properties, platelets are hypothesized to release certain antimicrobial peptides. Aim of present study is to evaluate antimicrobial activity of platelet-rich fibrin (PRF) preparation against periodontal pathogenic bacteria.
Methods: Subgingival plaque samples and blood samples from fifteen generalized chronic periodontitis patients were collected. Antimicrobial activity of PRF preparation against periodontal bacteria was assessed. Disc diffusion method and colorimetric analysis were employed to quantify the inhibitory effects.
Results: PRF demonstrated clear zone of inhibition in disc diffusion method and showed minimum amount of turbidity confirmed by colorimetric analysis. This clearly indicates possible bactericidal activity against gram-negative periodontopathic bacteria.
Conclusion: Apart from being excellent regenerative material, through its antibacterial effects, PRF can provide additional benefits at periodontal surgical sites.

PRF, Periodontal pathogens, Antibacterial agent, Disc diffusion, Colorimetry

Doi No:-10.18231