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International Journal of Pharmaceutical Chemistry and Analysis


Synthesis and Antimicrobial Activity of Novel 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide Derivatives


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Author Details : Pankaj Baboo, S.K.Gupta

Volume : 2, Issue : 3, Year : 2015

Article Page : 130-135


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Abstract

Ethyl N-Succinimido acetate was synthesized by equimolar condensation of succinimide and ethylchloroacetate by refluxing in presence of anhydrous potassium carbonate. Then Ethyl N-succinimido acetate was refluxed with hydrazine hydrate in presense of 1, 4-dioxane to obtain N-Succinimido acetylhydrazide, which was further treated with benzaldehyde to get phenyl succinimido acetylhydrazide, this compound was cyclized with mercaptoacetic acid to get the 3-(2-phenyl 4-oxo-1,3-thiazolidine) acetamido succinimide which was reacted with various aldehyde to get the 5-Arylidene-3-(2-phenyl 4-oxo-1,3-thiazolidine) succinimido aceto hydrazide. The formation of title compounds confirmed by physical and spectral data. The synthesized compounds were subjected to microbiological screening.

Keywords:
Thiazolidinone derivatives, 5-Arylidene-3-(2-phenyl 4-oxo-1,3-thiazolidine) succinimido aceto hydrazide, antimicrobial activity.

How to cite : Baboo P, S.k.gupta, Synthesis and Antimicrobial Activity of Novel 5-Arylidene-3-(2-phenyl 4-oxo-1, 3-thiazolidine) succinimido aceto hydrazide Derivatives. Int J Pharm Chem Anal 2015;2(3):130-135

Copyright © 2015 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)