Print ISSN:-2394-2789

Online ISSN:-2394-2797

CODEN : IJPCN9

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International Journal of Pharmaceutical Chemistry and Analysis


Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents


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Author Details : Paul Jacob, Beena Thomas, Neethu Santhosh

Volume : 5, Issue : 1, Year : 2018

Article Page : 16-23


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Abstract

Thiadiazole derivatives are reported to have various biological activities including antihyperlipidemia. In the present study a series of N-phenyl-1, 3, 4-thiadiazol-2-amine derivatives were designed using various softwares like Molinspiration, Schrodinger etc. The derivatives with optimum properties were synthesized and characterized using FT-IR, 1HNMR and MASS spectroscopy. In vivo screening for antihyperlipidemic activity in triton X-100 induced models showed moderate activity in comparison with standard.

Keywords: Thiadiazole, Antihyperlipidemia, Triton X-100, Atorvastatin.

Doi : 10.18231/2394-2797.2018.0004

How to cite : Jacob P, Thomas B, Santhosh N, Design, synthesis and biological evaluation of novel thiadiazole derivatives as antihyperlipidemic agents. Int J Pharm Chem Anal 2018;5(1):16-23

Copyright © 2018 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)