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International Journal of Pharmaceutical Chemistry and Analysis


Simultaneous quantitative estimation of Telmisartan and Hydrochlorothiazide in bulk and marketed tablet formulation by HPTLC-a Stability indicating method


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Author Details : Vrushali Tambe, Meenakshi Deodhar, Vijayalakshmi Prakya

Volume : 4, Issue : 3, Year : 2017

Article Page : 88-97


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Abstract

A stability indicating HPTLC method is proposed for the simultaneous estimation of telmisartan and hydrochlorothiazide in bulk and tablet formulation. Well resolved chromatogram was obtained on TLC plates coated with silica gel 60F254 with densitometric detection at 233 nm. Two drugs were satisfactorily resolved with Rf 0.21± 0.02 and 0.53± 0.02 for Telmisartan and Hydrochlorothiazide respectively. Linearity was found in the range of 0.18-5.76 µg / band (r2 = 0.999) for telmisartan and 0.056-1.6 µg/ band (r2 = 0.999) for Hydrochlorothiazide. The % recovery for analytes were in the range of 98.5-101.6 % w/w. Drugs were subjected to stress conditions like acid, base, neutral hydrolysis, oxidative, photolytic and thermal stress. Hydrochlorothiazide was found to be more prone to degradation than telmisartan. Both drugs were oxidised fast as compared under other stress conditions. Peak purity has indicated no interference from numerous degradation products formed with the analysis of drugs.

Keywords
: Telmisartan, Hydrochlorothiazide, Stability, HPTLC, Validation, Stress

How to cite : Tambe V, Deodhar M, Prakya V, Simultaneous quantitative estimation of Telmisartan and Hydrochlorothiazide in bulk and marketed tablet formulation by HPTLC-a Stability indicating method. Int J Pharm Chem Anal 2017;4(3):88-97

Copyright © 2017 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)