IP International Journal of Orthopaedic Rheumatology

Intra-articular injection of bone marrow concentrate protocol for Osteoarthritis – A preliminary report with 12 months follow up

Full Text PDF

Author Details: VR Ravi, Avinash Gandhi, S. Sankaranarayanan, K. Manimaran

Volume : 3

Issue : 1

Online ISSN : 2581-9151

Print ISSN : 2581-8112

Article First Page : 8

Article End Page : 14


Osteoarthritis – a degenerative joint disorder by loss of cartilage leading to pain and physical function of the patients. Most existing Intra articular injections show promising results in pain relief but none have regenerative potentials. With the existing published evidences and clinical trial an attempt was made by Intra articular injection of autologous bone marrow concentrate in 10 Osteoarthritis patients with 12 months follow up. Bone marrow was concentrated using protocols of Biosafe Sepax and on an average 7ml of concentrate was injected in each defective knee. Patients showed improvements by pain relief and physical function. Apart from WOMAC pain score and VAS the improvement was also found in increase of joint space and cartilage volume evident from post-operative X ray and MRI, which might be due to the regeneration of cartilage. No adverse events were noted in this study.

: Bone marrow Concentrate, Bone marrow mononuclear cells, Knee osteoarthritis, Biological regeneration

Doi No:-10.18231