Print ISSN:-2394-6369

Online ISSN:-2394-6377


Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 666

Emailed: 0

PDF Downloaded: 332

International Journal of Clinical Biochemistry and Research

Study of dyselectrolytemia in patients with multiple myeloma

Full Text PDF Share on Facebook Share on Twitter

Author Details : Madanika P, Malathi M, Ramlingareddy

Volume : 5, Issue : 3, Year : 2018

Article Page : 397-400

Suggest article by email


Multiple myeloma (MM) is a malignant disease of plasma cells characterized by proliferation of a specific myelomatous clone of cells. It is second most common hematologic cancer. Renal impairment is observed in nearly half of the patients with multiple myeloma and 20% progress to renal failure due to precipitation of excess proteins in tubuli. Hyperproteinemia is associated with low plasma water levels causing unrealistically low electrolyte levels. Hyponatremia is one of the most commonly observed electrolyte disturbance. Evaluation of dyselectrolytemia in these patients and association with renal disease is useful in management and helps in monitoring prognosis. We conducted a cross sectional study on 31 newly confirmed cases of Multiple Myeloma diagnosed by serum protein electrophoresis, bone marrow aspiration and biopsy in Mangalore. Electrolyte disturbances observed include hypercalcemia (13%), hyponatremia (42%) and hypokalemia (6%). Hypoalbuminemia was observed in 83% of cases. Renal impairment was seen in 58% cases. Serum osmolarity was low despite increased proteins. Electrolyte disturbances are not uncommon in multiple myeloma. Hyponatremia can be asymptomatic and demands careful evaluation before institution of therapy. It is important to measure serum osmolarity and osmolar gap and carefully decide the management of electrolyte imbalance in every case of multiple myeloma. The coexistent hyperproteinemia, hyperglycemia, hypertriglyceridemia and renal disease should be evaluated. Hyponatremia was common in our study group although association with proteins or renal disease was not statistically significant.

Keywords: Dyselectrolytemia in Multiple myeloma, Pseudohyponatremia.

Doi : 10.18231/2394-6377.2018.0083

How to cite : Madanika P, Malathi M, Ramlingareddy, Study of dyselectrolytemia in patients with multiple myeloma. Int J Clin Biochem Res 2018;5(3):397-400

Copyright © 2018 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (