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International Journal of Clinical Biochemistry and Research

Zinc as an auxiliary marker along with Cancer Antigen 125 in ovarian cancer

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Research Article

Author Details : Ravindra Maradi*, Nisha Abdul Khader, Kishan K

Volume : 6, Issue : 4, Year : 2019

Article Page : 601-605

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Ovarian cancer is the most common and most lethal gynecologic malignancy. It is one of the most leading
cancers in Indian women. The urge for the early detection of ovarian cancer continues to be one of the most
important issues in women’s health care. The cause for ovarian cancer may be due to increased oxidative
stress, heredity, dietary deficiency etc. As zinc is essential for cytotoxic/tumor suppressor effect and it plays
very important role in cancer progression. In ovarian cancer the level of zinc in blood is usually decreased.
So, the hypothesis of the study is to know the association between the serum zinc levels and the ovarian
cancer marker, CA125. Aim of the study is to correlate the serum Zinc levels with serum CA 125 in healthy
controls and ovarian cancer subjects.
Totally 90 subjects are enrolled in the study. Out of this 74 were controls and 16 were ovarian cancer
subjects. The serum CA 125 was increased in ovarian cancer patients compared to controls. Whereas,
serum Zinc was decreased in ovarian cancer patients compared to controls. As well as there was indeed a
strong association of serum Zinc and CA 125 in ovarian cancer patients.
Hence measurement of serum Zinc, an inexpensive assay could be used as an auxiliary marker along with
CA 125 in screening of ovarian cancer.

Keywords: Zinc, Ovarian cancer, Marker CA 125, Serum CA 125.

Doi : 10.18231/j.ijcbr.2019.124

How to cite : Maradi R, Khader N A, Kishan K, Zinc as an auxiliary marker along with Cancer Antigen 125 in ovarian cancer. Int J Clin Biochem Res 2019;6(4):601-605

Copyright © 2019 by author(s) and Int J Clin Biochem Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (