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Indian Journal of Clinical Anaesthesia


To Evaluate the Efficacy and Safety of Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Laproscopic Cholecystectomy


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Author Details : Sapna Bansal, Sachin Bansal, Shruti Saini, Dhanwant Kaur, Apoorva Kaul, Jaggy

Volume : 2, Issue : 3, Year : 2015

Article Page : 146-150


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Abstract

Introduction: Peritoneal insufflation of intra-abdominal pressure >10 mmHg induces a significant alteration of hemodynamics. Use of α-2 adrenergic agonists Dexmedetomidine significantly reduces hemodynamic changes and anesthetic requirements as it has sedative, analgesic, and anxiolytic properties.

Methods: 100 patients of ASA I- II undergoing laparoscopic cholecystectomy were randomly allocated into two groups of 50 patients each. Group I patients received dexmedetomidine infusion at 0.2μg/kg/hr and Group II patients received normal saline infusion at 0.2μg/kg/h starting after intubation and continued till peritoneal deflation. Parameters noted were pulse rate, mean arterial pressure, oxygen saturation, EtCO2 and isoflurane requirement.
Results: In dexmedetomidine group, the haemodynamic response was significantly attenuated. The anaesthetic requirement was also less with dexmedetomidine group without any desaturation.
Conclusion: Dexmedetomidine infusion in the dose of 0.2μg/kg/h effectively attenuates haemodynamic stress response to pneumoperitoneum during laparoscopic surgery.

Key words: Dexmedetomidine, haemodynamic stress response, laparoscopic cholecystectomy, pmeumoperitoneum.

How to cite : Bansal S, Bansal S, Saini S, Kaur D, Kaul A, Jaggy, To Evaluate the Efficacy and Safety of Dexmedetomidine on Hemodynamic Stability in Patients Undergoing Laproscopic Cholecystectomy. Indian J Clin Anaesth 2015;2(3):146-150

Copyright © 2015 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)