Print ISSN:-2394-4781

Online ISSN:-2394-4994

CODEN : IJCACT

Current Issue

Year 2020

Volume: 7 , Issue: 2

Article Access statistics

Viewed: 657

Emailed: 0

PDF Downloaded: 180

Indian Journal of Clinical Anaesthesia


A study of intubating conditions and haemodynamic characteristics using propofol and rocuronium after pre-treatment with ephedrine


Full Text PDF Share on Facebook Share on Twitter


Author Details : Vidushi S, Devesh S, Asrar M, Meenaxi S, Anumeha J

Volume : 3, Issue : 2, Year : 2016

Article Page : 300-315


Suggest article by email

Abstract

Background and Objectives: The present study was conducted to compare the efficacy of Pre-treatment with a low dose of intravenous ephedrine 70 μg kg-1 on the intubating conditions and its effects on hemodynamic during rapid tracheal intubation using propofol 2.5 mg kg-1 and rocuronium bromide 0.6 mg kg-1.
Methodology: In this study one hundred patients were included and randomly divided into two equal groups which received either ephedrine 70 μg kg-1 diluted to 5 ml with normal saline (Group EPR) or 5 ml of normal saline (Group SPR) 3 min prior to laryngoscopy and intubation with Propofol 2.5 mg kg-1 and rocuronium bromide 0.6 mg kg-1. A blinded anaesthesiologist assessed the intubating conditions; heart rate and mean arterial pressure before anaesthesia induction (baseline), and every minute thereafter till5 minutes post intubation. A 30% change in hemodynamic variables from baseline was regarded as clinically significant. Data were analyzed using Paired samples t-test.
Results: Intubating conditions were better (p=0.023) in the ephedrine pre-treated group. There was no statistically significant difference between the ephedrine pre-treated group and control regarding the time taken for laryngoscopy and intubation. There were no significant hemodynamic changes between the two groups except tachycardia.
Conclusion: Ephedrine 70 μg kg-1 prior to induction with propofol 2.5 mg kg-1 improves intubating conditions compared to propofol alone 1 minute after 0.6 mg kg-1 rocuronium bromide injection without significant hemodynamic effects.

Key Words: Ephedrine; Rocuronium; Propofol; Rapid tracheal intubation

 

How to cite : Vidushi S, Devesh S, Asrar M, Meenaxi S, Anumeha J, A study of intubating conditions and haemodynamic characteristics using propofol and rocuronium after pre-treatment with ephedrine. Indian J Clin Anaesth 2016;3(2):300-315

Copyright © 2016 by author(s) and Indian J Clin Anaesth. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC-BY-NC 4.0) (creativecommons.org)