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IP Archives of Cytology and Histopathology Research

Clinical and histopathological correlation in leprosy: A two year prospective study

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Research Article

Author Details : Balaji T G*, A M Patil, Saeed M Yendigeri

Volume : 4, Issue : 4, Year : 2019

Article Page : 301-304

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Background: Leprosy is known to man since ancient times. Leprosy bacillus was discovered by
Gerhard Henrick Armauer Hansen in 1873. Ridley-Jopling classification takes into consideration clinical,
bacteriological, histopathological and immunological factor. The present study was done to correlate
clinical and histopathological diagnosis.
Materials and Methods : Fifty newly diagnosed cases of leprosy were included in the study during the
period from August 2011 to August 2013. H and E stained sections were observed for histopathological
features and classified according to Ridley & Jopling classification and a clinicopathological correlation
was made.
Result: Maximum numbers of cases diagnosed histopathologically belonged to borderline tuberculoid
18(36%) cases. Hundred percent correlation was seen between clinical diagnosis and histopathological
diagnosis in tuberculoid leprosy. The overall clinico-histopathological correlation in our study was 62%.
Conclusion: Histopathological classification is accurate as it considers immunologic response of the tissue,
whereas clinical classification considers only gross appearances of the lesions. Borderline leprosy cases are
in a continuous changing immunological spectrum and histopathologic classification identifies any recent
shift of a case in the spectrum.

Keywords: Histopathology, Leprosy, Ridley-Jopling’s classification.

Doi : 10.18231/j.achr.2019.057

How to cite : Balaji T G, Patil A M, Yendigeri S M, Clinical and histopathological correlation in leprosy: A two year prospective study. IP Arch Cytol Histopathol Res 2019;4(4):301-304

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