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IP Archives of Cytology and Histopathology Research

Comparative study of female hypothyroid patients having autoimmune thyroiditis with the clinico-pathological parameters

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Research Article

Author Details : Goutami Dasnayak, Prajna Das*, Kanakalata Dash

Volume : 4, Issue : 4, Year : 2019

Article Page : 288-292

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Introduction: Hypothyroidism during reproductive age group is responsible for menstrual irregularities,
infertility along with miscarriages and congenital malformation s during pregnancy. It has a prevalence of
5-20% in child bearing age. Autoimmune thyroiditis is the common cause of subclinical hypothyroidism
in adult female population. Presence of thyroid autoantibodies is high in subclinical hypothyroidism.
American Thyroid Association (ATA) & American Association of Clinical Endocrinologist (AACE)
recommends for treatment of these patients. Lack of obvious signs and symptoms in subclinical
hypothyroidism creates dilemma and challenge for diagnosis.
Hypothesis: This was a retrospective study conducted in Kalinga Institute of Medical Sciences (KIMS),
Bhubaneswar during the period from January 2017 to January 2019. Women of reproductive age group
having thyroid swellings were subjected to Fine needle aspiration cytology (FNAC), Thyroid function
test and Anti TPO Ab levels in serum. Cytological grading was done and it was correlated with clinical
presentation and serological parameters.
Results: Out of 120 cases, 56.7% patients were hypothyroid. Increased titre of Anti- TPO Ab levels
in serum was observed in 91.4%, 95.3% and 95% cases of Grade I, Grade II & Grade III categories of
autoimmune thyroiditis respectively.
Conclusion: Autoimmune thyroiditis is the common cause of hypothyroidism in adult females. Early
detection and management with low dose of thyroxine will prevent the complications during reproductive

Keywords: Autoimmune thyroiditis, Hypothyroidism, Anti-TPO Antibody, TFT.

Doi : 10.18231/j.achr.2019.054

How to cite : Dasnayak G, Das P, Dash K, Comparative study of female hypothyroid patients having autoimmune thyroiditis with the clinico-pathological parameters. IP Arch Cytol Histopathol Res 2019;4(4):288-292

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